Disclaimer

The system provides an estimate of in vivo efficacy of commonly used antiretroviral drug combinations based on user-defined information of HIV genotype (mandatory) and additional patient information (recommended). The engine is not intended as a replacement for standard of care but can be used by HIV specialists as an additional treatment decision support tool. Although analysis of a large data set of medical records has shown a good performance of the system, there is no warranty that its use will improve patient health. HIV care must rely on a solid knowledge of the complex host-virus interaction and proper consideration of patient status and commitment.



EuResist prediction system

The EuResist project has developed an integrated computational system for clinical management of antiretroviral drug resistance. The system requests HIV genotype and optionally a set of clinical data and returns a prediction of response to common antiretroviral regimens, helping the HIV specialist to choose the most effective drug combinations for her/his patient.

Nov 2015 update: longer term prediction model

The system has been re-trained and tested in November 2015 on a set of data derived from clinical practice records of more than 66,000 HIV patients collected in Europe. The internal validation showed a prediction accuracy of 73-76% (AUROC) when treatment success was defined as achieving a decrease of at least 2 log or an undetectable HIV RNA load at week 48 after treatment start (it was week 8 in the previous model). read more.

The EuResist system is a linear combination of three statistical learning engines predicting response to treatment. These were designed to work with viral genotype and intended regimen as the only information, as well as with additional measurements (e.g. baseline viral load) and information derived from previous treatments and genotypes to enhance prediction performance. The models combined in the final prediction system include: a Generative Discriminative engine using a Bayesian Network prediction as an additional covariate, a Mixed Effects engine modelling interactions between covariates, and an Evolutionary engine exploiting the genetic barrier to drug resistance as an additional predictor. read more.

EuResist integrated database

The EuResist Integrated DataBase (EIDB) was set up to develop the EuResist prediction system. It is available for scientific purposes upon request. The EIDB includes information about patient demographics, drug therapies, AIDS defining events, CD4 and viral load measurements, and HIV sequences. As of April 2018 it contains the following data:

Patients 81.227
CD4 counts 1.126.492
ENV 196
GP120 sequences 3.952
GP41 sequences 1.389
IN sequences 8.165
PR sequences 79.809
RT sequences 80.367
Therapies 172.140
V3 sequences 1.071
Viral Load data 1.118.249

The EIDB integrates biomedical information from the three founding national databases: ARCA (Italy), AREVIR (Germany), Karolinska Institute (Sweden). The original data set is continuously updated with new data in order to improve the accuracy of the prediction system. Following the EIDB setup, data have also been uploaded from the Laboratoire de Rétrovirologie of CRP-Santé (Luxembourg), the Rega Institute (Leuven - Belgium), the IrsiCaixa Foundation (Barcelona – Spain), the Instituto de Higiene e Medicina Tropical (Portugal) and from the DUET study (Tibotec). read more.

Contribution to the database

The service is and will remain free of charge. Like any data-driven engine, availability of new data is crucial for updating and improving the system. You can contribute genotype-response data to the EuResist initiative under the current regulations. (database). The EuResist data set is available upon request for scientific studies related to HIV domain.

Authors

  • Abbott
    EuResist Network received a grant from Abbott
  • The EuResist project has been supported by the EC within the Sixth Framework Programme
  • Pfizer
    EuResist Network received a grant from Pfizer

Dettagli richiesta
ID sessione:4zd0xqmkcdwhb0xyvp34z411Tipo richiesta:GET
Data e ora della richiesta:25/01/2020 11:41:32Codice stato:200
Codifica richiesta:Europa occidentale (ISO)Codifica risposta:Unicode (UTF-8)

Informazioni traccia
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           <compound>11</compound>
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         <treatment>
           <compound>6</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>21</compound>
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         <treatment>
           <compound>8</compound>
           <compound>12</compound>
           <compound>15</compound>
           <compound>20</compound>
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         <treatment>
           <compound>1</compound>
           <compound>6</compound>
           <compound>15</compound>
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         <treatment>
           <compound>2</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>23</compound>
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         <treatment>
           <compound>1</compound>
           <compound>2</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>7</compound>
           <compound>17</compound>
           <compound>20</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>13</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>6</compound>
           <compound>13</compound>
         </treatment>
         <treatment>
           <compound>8</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>22</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>6</compound>
           <compound>15</compound>
           <compound>20</compound>
         </treatment>
         <treatment>
           <compound>6</compound>
           <compound>12</compound>
           <compound>15</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>2</compound>
           <compound>20</compound>
           <compound>23</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>7</compound>
           <compound>20</compound>
           <compound>21</compound>
         </treatment>
         <treatment>
           <compound>6</compound>
           <compound>11</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
           <compound>2</compound>
           <compound>12</compound>
           <compound>17</compound>
           <compound>20</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>6</compound>
           <compound>20</compound>
           <compound>22</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>6</compound>
           <compound>12</compound>
         </treatment>
         <treatment>
           <compound>8</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>7</compound>
           <compound>15</compound>
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         <treatment>
           <compound>2</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>21</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>2</compound>
           <compound>17</compound>
           <compound>20</compound>
         </treatment>
         <treatment>
           <compound>4</compound>
           <compound>12</compound>
           <compound>15</compound>
           <compound>20</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>4</compound>
           <compound>11</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>3</compound>
           <compound>15</compound>
           <compound>20</compound>
         </treatment>
         <treatment>
           <compound>8</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>23</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>6</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>13</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
           <compound>2</compound>
           <compound>12</compound>
           <compound>15</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>2</compound>
           <compound>20</compound>
           <compound>21</compound>
         </treatment>
         <treatment>
           <compound>4</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>22</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>3</compound>
           <compound>11</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>4</compound>
           <compound>13</compound>
         </treatment>
         <treatment>
           <compound>2</compound>
           <compound>11</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>3</compound>
           <compound>20</compound>
           <compound>22</compound>
         </treatment>
         <treatment>
           <compound>8</compound>
           <compound>12</compound>
           <compound>17</compound>
           <compound>20</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>6</compound>
           <compound>20</compound>
           <compound>23</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>2</compound>
           <compound>15</compound>
         </treatment>
         <treatment>
           <compound>4</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
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         </treatment>
         <treatment>
           <compound>1</compound>
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         <treatment>
           <compound>1</compound>
           <compound>3</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
           <compound>8</compound>
           <compound>12</compound>
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         <treatment>
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           <compound>15</compound>
           <compound>20</compound>
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         <treatment>
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           <compound>12</compound>
           <compound>20</compound>
           <compound>23</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>3</compound>
           <compound>12</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>7</compound>
           <compound>11</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>12</compound>
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           <compound>20</compound>
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         <treatment>
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           <compound>11</compound>
           <compound>20</compound>
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         <treatment>
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           <compound>20</compound>
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         </treatment>
         <treatment>
           <compound>4</compound>
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         <treatment>
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           <compound>11</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>22</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>3</compound>
           <compound>17</compound>
           <compound>20</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>6</compound>
           <compound>15</compound>
         </treatment>
         <treatment>
           <compound>1</compound>
           <compound>7</compound>
           <compound>13</compound>
         </treatment>
         <treatment>
           <compound>3</compound>
           <compound>7</compound>
           <compound>20</compound>
           <compound>24</compound>
         </treatment>
         <treatment>
           <compound>4</compound>
           <compound>12</compound>
           <compound>20</compound>
           <compound>21</compound>
         </treatment>
         <treatment>
           <compound>7</compound>
           <compound>8</compound>
           <compound>13</compound>
         </treatment>
       </suggestedTreatments>
     </patient>
   </n1:Request>
 </env:Body>
</env:Envelope>		0,0268550,020011
<?xml version="1.0" encoding="utf-8"?><soap:Envelope xmlns:soap="http://schemas.xmlsoap.org/soap/envelope/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><soap:Body><Response xmlns="http://euresist"><admin xmlns=""><statusCode>0</statusCode><status>

&lt;?xml version="1.0"?&gt;
&lt;Patient xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"&gt;
 &lt;baselineGenotype&gt;
   &lt;pro&gt;
     &lt;startPos&gt;14&lt;/startPos&gt;
     &lt;endPos&gt;93&lt;/endPos&gt;
     &lt;date&gt;2012-09-24&lt;/date&gt;
     &lt;mutation&gt;
       &lt;position&gt;14&lt;/position&gt;
       &lt;aa&gt;R&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;16&lt;/position&gt;
       &lt;aa&gt;E&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;36&lt;/position&gt;
       &lt;aa&gt;I&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;41&lt;/position&gt;
       &lt;aa&gt;K&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;63&lt;/position&gt;
       &lt;aa&gt;V&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;69&lt;/position&gt;
       &lt;aa&gt;K&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;89&lt;/position&gt;
       &lt;aa&gt;M&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;93&lt;/position&gt;
       &lt;aa&gt;L&lt;/aa&gt;
     &lt;/mutation&gt;
   &lt;/pro&gt;
   &lt;rt&gt;
     &lt;startPos&gt;35&lt;/startPos&gt;
     &lt;endPos&gt;317&lt;/endPos&gt;
     &lt;date&gt;2012-09-24&lt;/date&gt;
     &lt;mutation&gt;
       &lt;position&gt;35&lt;/position&gt;
       &lt;aa&gt;T&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;36&lt;/position&gt;
       &lt;aa&gt;A&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;39&lt;/position&gt;
       &lt;aa&gt;D&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;98&lt;/position&gt;
       &lt;aa&gt;S&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;122&lt;/position&gt;
       &lt;aa&gt;E&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;123&lt;/position&gt;
       &lt;aa&gt;S&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;158&lt;/position&gt;
       &lt;aa&gt;S&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;165&lt;/position&gt;
       &lt;aa&gt;I&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;173&lt;/position&gt;
       &lt;aa&gt;A&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;174&lt;/position&gt;
       &lt;aa&gt;K&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;177&lt;/position&gt;
       &lt;aa&gt;E&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;196&lt;/position&gt;
       &lt;aa&gt;E&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;200&lt;/position&gt;
       &lt;aa&gt;A&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;202&lt;/position&gt;
       &lt;aa&gt;V&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;207&lt;/position&gt;
       &lt;aa&gt;E&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;245&lt;/position&gt;
       &lt;aa&gt;Q&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;250&lt;/position&gt;
       &lt;aa&gt;E&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;272&lt;/position&gt;
       &lt;aa&gt;P&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;288&lt;/position&gt;
       &lt;aa&gt;T&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;292&lt;/position&gt;
       &lt;aa&gt;I&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;293&lt;/position&gt;
       &lt;aa&gt;V&lt;/aa&gt;
     &lt;/mutation&gt;
     &lt;mutation&gt;
       &lt;position&gt;317&lt;/position&gt;
       &lt;aa&gt;A&lt;/aa&gt;
     &lt;/mutation&gt;
   &lt;/rt&gt;
   &lt;subtype&gt;B&lt;/subtype&gt;
 &lt;/baselineGenotype&gt;
 &lt;patientData&gt;
   &lt;age&gt;28&lt;/age&gt;
   &lt;gender&gt;1&lt;/gender&gt;
   &lt;riskGroup&gt;3&lt;/riskGroup&gt;
 &lt;/patientData&gt;
 &lt;clinicalMeasures&gt;
   &lt;baselineViralLoad&gt;1130&lt;/baselineViralLoad&gt;
   &lt;baselineCd4&gt;290&lt;/baselineCd4&gt;
 &lt;/clinicalMeasures&gt;
 &lt;historicalData&gt;
   &lt;numberOfPastTreatmentLines&gt;0&lt;/numberOfPastTreatmentLines&gt;
   &lt;pastTreatments /&gt;
 &lt;/historicalData&gt;
 &lt;suggestedTreatments /&gt;
&lt;/Patient&gt;

Age
Gender
Risk
Subtype
Baseline_vl
Baseline_cd4
Historical data
PR_muts
RT_muts
Suggested treatments
Save input file
THERAPYID;THER;H_THER;PR_MUTS;RT_MUTS;AGE;GENDER;RISK;NUMBER_OF_PAST_TREATMENT_LINES;SUBTYPE;BASELINE_VL;BASELINE_CD4

Run java class
Complete</status><engineType>IPRO ASP.NET/C#/2016</engineType></admin></Response></soap:Body></soap:Envelope>		0,5644300,537575
aspx.pageEnd Load0,5655590,001129
aspx.pageBegin LoadComplete0,5655770,000018
aspx.pageEnd LoadComplete0,5655850,000007
aspx.pageBegin PreRender0,5655910,000007
aspx.pageEnd PreRender0,5656040,000013
aspx.pageBegin PreRenderComplete0,5656140,000010
aspx.pageEnd PreRenderComplete0,5656200,000007
aspx.pageBegin SaveState0,5658250,000205
aspx.pageEnd SaveState0,5661310,000306
aspx.pageBegin SaveStateComplete0,5661420,000011
aspx.pageEnd SaveStateComplete0,5661490,000007
aspx.pageBegin Render0,5661550,000006
aspx.pageEnd Render0,5688170,002662

Struttura ad albero controlli
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            ctl00$ctl05System.Web.UI.ResourceBasedLiteralControl36700
            ctl00$ctl02System.Web.UI.HtmlControls.HtmlLink8100
            ctl00$ctl03System.Web.UI.HtmlControls.HtmlLink8000
            ctl00$headSystem.Web.UI.WebControls.ContentPlaceHolder400
                ctl00$head$ctl00System.Web.UI.LiteralControl400
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            ctl00$ctl06System.Web.UI.ResourceBasedLiteralControl57600
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            ctl00$ContentPlaceHolder1System.Web.UI.WebControls.ContentPlaceHolder698700

Stato sessione
Chiave sessioneTipoValore

Stato applicazione
Chiave applicazioneTipoValore

Raccolta cookie di richiesta
NomeValoreDimensione

Raccolta cookie di risposta
NomeValoreDimensione
ASP.NET_SessionId4zd0xqmkcdwhb0xyvp34z41142

Raccolta Headers
NomeValore
ConnectionKeep-Alive
Content-Length0
Accepttext/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8
Accept-Encodingbr,gzip
Accept-Languageen-US,en;q=0.5
Hostengine.euresist.org
If-Modified-SinceTue, 10 Dec 2019 17:15:36 PST
User-AgentCCBot/2.0 (https://commoncrawl.org/faq/)
X-Forwarded-For100.26.179.196
X-Forwarded-Hostengine.euresist.org
X-Forwarded-Server31.193.128.106

Raccolta intestazioni di risposta
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X-AspNet-Version4.0.30319
Set-CookieASP.NET_SessionId=4zd0xqmkcdwhb0xyvp34z411; path=/; HttpOnly
Cache-Controlprivate
Content-Typetext/html

Raccolta Form
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Raccolta Querystring
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Variabili server
NomeValore
ALL_HTTPHTTP_CONNECTION:Keep-Alive HTTP_CONTENT_LENGTH:0 HTTP_ACCEPT:text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8 HTTP_ACCEPT_ENCODING:br,gzip HTTP_ACCEPT_LANGUAGE:en-US,en;q=0.5 HTTP_HOST:engine.euresist.org HTTP_IF_MODIFIED_SINCE:Tue, 10 Dec 2019 17:15:36 PST HTTP_USER_AGENT:CCBot/2.0 (https://commoncrawl.org/faq/) HTTP_X_FORWARDED_FOR:100.26.179.196 HTTP_X_FORWARDED_HOST:engine.euresist.org HTTP_X_FORWARDED_SERVER:31.193.128.106
ALL_RAWConnection: Keep-Alive Content-Length: 0 Accept: text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8 Accept-Encoding: br,gzip Accept-Language: en-US,en;q=0.5 Host: engine.euresist.org If-Modified-Since: Tue, 10 Dec 2019 17:15:36 PST User-Agent: CCBot/2.0 (https://commoncrawl.org/faq/) X-Forwarded-For: 100.26.179.196 X-Forwarded-Host: engine.euresist.org X-Forwarded-Server: 31.193.128.106
APPL_MD_PATH/LM/W3SVC/12/ROOT
APPL_PHYSICAL_PATHC:\_IISWebFolder\_ENGINE2\
AUTH_TYPE 
AUTH_USER 
AUTH_PASSWORD 
LOGON_USER 
REMOTE_USER 
CERT_COOKIE 
CERT_FLAGS 
CERT_ISSUER 
CERT_KEYSIZE 
CERT_SECRETKEYSIZE 
CERT_SERIALNUMBER 
CERT_SERVER_ISSUER 
CERT_SERVER_SUBJECT 
CERT_SUBJECT 
CONTENT_LENGTH0
CONTENT_TYPE 
GATEWAY_INTERFACECGI/1.1
HTTPSoff
HTTPS_KEYSIZE 
HTTPS_SECRETKEYSIZE 
HTTPS_SERVER_ISSUER 
HTTPS_SERVER_SUBJECT 
INSTANCE_ID12
INSTANCE_META_PATH/LM/W3SVC/12
LOCAL_ADDR127.0.0.1
PATH_INFO/default.aspx
PATH_TRANSLATEDC:\_IISWebFolder\_ENGINE2\default.aspx
QUERY_STRING 
REMOTE_ADDR127.0.0.1
REMOTE_HOST127.0.0.1
REMOTE_PORT52102
REQUEST_METHODGET
SCRIPT_NAME/default.aspx
SERVER_NAMEengine.euresist.org
SERVER_PORT8080
SERVER_PORT_SECURE0
SERVER_PROTOCOLHTTP/1.1
SERVER_SOFTWAREMicrosoft-IIS/7.5
URL/default.aspx
HTTP_CONNECTIONKeep-Alive
HTTP_CONTENT_LENGTH0
HTTP_ACCEPTtext/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8
HTTP_ACCEPT_ENCODINGbr,gzip
HTTP_ACCEPT_LANGUAGEen-US,en;q=0.5
HTTP_HOSTengine.euresist.org
HTTP_IF_MODIFIED_SINCETue, 10 Dec 2019 17:15:36 PST
HTTP_USER_AGENTCCBot/2.0 (https://commoncrawl.org/faq/)
HTTP_X_FORWARDED_FOR100.26.179.196
HTTP_X_FORWARDED_HOSTengine.euresist.org
HTTP_X_FORWARDED_SERVER31.193.128.106
Versione di Microsoft .NET Framework:4.0.30319; Versione di ASP.NET:4.8.4042.0